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Magnesium Threonate: What You Need To Know Now In 2023

Magnesium Threonate Supplements are special as its crosses the Blood Brain Barrier and increases Brains Magnesium Levels and ultimately improves Cognitive functions

Magnesium Threonate has taken center stage in the realm of cognitive enhancement and brain health. This unique compound, also known as Magnesium L-threonate, has gained significant attention for its potential benefits in boosting cognitive function. In this article, we will explore the brief overview of Mg Threonate, shedding light on its intriguing properties and the potential it holds for enhancing brain health.

Magnesium Threonate: A Unique Compound

Mg Threonate distinguishes itself from other forms of magnesium due to its remarkable ability to traverse the blood-brain barrier effectively. This barrier acts as a protective shield, regulating the passage of substances from the bloodstream into the brain. Unlike its counterparts, Magnesium Threonate demonstrates exceptional permeability through this barrier, allowing for improved access to the brain.

The mechanism by which Mg Threonate Supplement crosses the BBB( Blood Brain Barrier) is not fully understood, but researchers believe that its ability to do so is attributed to several factors:

  1. Molecular Size: Magnesium Threonate supplements has a smaller molecular size compared to other forms of magnesium.  Molecular formula C8H14MgO10. Molecular weight of approximately 294.5 g/mol.  This smaller size may allow it to pass through the tight junctions between the cells of the BBB more easily.
  2. Chelation: Magnesium Threonate is formed by combining magnesium ions with threonic acid, a derivative of the sugar threose. This chelation process may enhance the transport of magnesium across the BBB by utilizing specific transporters or channels.
  3. Threonate Transporters: Threonic acid, which is part of the Magnesium Threonate compound, may have specific transporters or carriers in the cells of the BBB. These transporters could facilitate the movement of Magnesium Threonate into the brain.

What is Magnesium Threonate good for?

1 . Cognitive Enhancement:  studies suggest that Magnesium Threonate supplementation may enhance learning and memory. It is believed to promote synaptic plasticity, which is crucial for the brain’s ability to change and adapt. By supporting neuronal communication and strengthening connections between brain cells, Magnesium Threonate may potentially enhance cognitive function.

2. Age-Related Cognitive Decline:  cognitive decline is a natural part of the aging process, but studies in animals have indicated that Magnesium Threonate might help protect against cognitive impairment associated with aging. It may have a positive impact on memory and cognitive performance, potentially slowing down age-related cognitive decline.

3. Neuroprotection: Mg Threonate may exhibit neuroprotective properties. It has been suggested to reduce neuroinflammation and oxidative stress, which are implicated in neurodegenerative conditions such as Alzheimer’s disease. By protecting brain cells from damage, it may contribute to overall brain health.

4. Mood and Sleep Support: Magnesium is known to play a role in mood regulation and sleep quality. While specific studies on Magnesium Threonate’s effects on mood and sleep are limited, adequate magnesium levels are essential for neurotransmitter balance and the production of melatonin, a hormone that regulates sleep. Therefore, optimizing magnesium levels through supplementation may indirectly support mood and sleep.

Magnesium Threonate dose

The recommended dosage of Magnesium Threonate may vary depending on factors such as age, overall health, and the specific formulation of the supplement. Typically, a common dosage range is around 1,000 to 2,000 milligrams (mg) per day, divided into two or three doses. However, it’s crucial to follow the instructions on the product label or the guidance of a healthcare professional.

When to take Magnesium Threonate

Magnesium Threonate can be taken with or without food, depending on personal preference and tolerance. Some individuals may find it more convenient to take it with a meal to minimize the potential for digestive discomfort, while others may prefer taking it on an empty stomach. Experimenting with different timings can help determine what works best for you.

Side Effects of Magnesium Threonate, Is it Safe?

Magnesium Threonate is generally safe for most individuals when taken at recommended dosages. However, like any supplement, it can potentially cause side effects or interact with certain individuals. Here are some important points to consider regarding the safety of Magnesium Threonate:

  1. Gastrointestinal Issues: Some individuals may experience digestive side effects such as diarrhea, stomach cramps, or nausea when taking Magnesium Threonate. These effects are more likely to occur if the recommended dosage is exceeded. If you experience any discomfort in your stomach or digestive system, it is advisable to reduce the dosage or consult with a healthcare professional.
  2. Interactions with Medications: Magnesium Threonate can interact with certain medications. For example, it may interfere with the absorption of some antibiotics, bisphosphonates (used for osteoporosis treatment), and certain medications for thyroid conditions. If you are taking any medications, it is essential to consult with your healthcare provider before starting Magnesium Threonate to ensure there are no potential interactions.
  3. Kidney Function: Individuals with impaired kidney function should use caution when taking magnesium supplements, including Magnesium Threonate. The kidneys play a role in regulating magnesium levels in the body, and excessive magnesium intake can put additional strain on the kidneys. If you have kidney disease or impaired kidney function, it is crucial to consult with a healthcare professional before starting any magnesium supplementation.
  4. Allergic Reactions: Although rare, some individuals may be allergic to magnesium supplements. If you experience symptoms such as rash, itching, swelling, or difficulty breathing after taking Magnesium Threonate, discontinue use immediately and seek medical attention.
  5. Individual Sensitivities: Everyone’s response to magnesium supplementation can vary. Some individuals may be more sensitive to magnesium supplements than others. It is important to pay attention to your body’s response and adjust the dosage accordingly. If you have any concerns or experience unusual side effects, it is recommended to consult with a healthcare professional.

Magnesium Threonate vs Glycinate:  Choosing the Right Magnesium Supplement for Your Needs

Magnesium threonate vs glycinate
Magnesium Threonate vs Glycinate


Magnesium Threonate stands out due to its remarkable ability to effectively cross the blood-brain barrier, resulting in elevated magnesium levels within the brain. This makes it a potentially beneficial choice for supporting cognitive function. In contrast, Magnesium Glycinate offers high absorbability and may be more suitable for individuals who have magnesium deficiency or those looking to supplement their overall magnesium intake.

Remember, personalized advice is invaluable when it comes to choosing the right Magnesium supplement. Always prioritize your individual needs and consult with a healthcare professional to ensure safety and efficacy.




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